Given its low cost and medical potential and considering its relative safety if used properly, we suggest that randomized controlled trials should be conducted.

None of the twenty-eight caregivers in close contact with the patients reported contracting COVID-19.

Patients frequently reported nausea and sometimes dizziness or vomiting related to the oral treatment. Two (9%) were hospitalized prior to joining the study, and one did not fully recover. The patients mainly recovered well, reporting feeling “completely better” at 9.5 days on average. We describe the treatment program and report the response of the COVID-19 patients and their caregivers. We report a consecutive case series of twenty-three COVID-19 patients (of 36 initially enrolled) who had been diagnosed by their primary care physician (mean age: 39, range: 8 months–70 years 74% male) and twenty-eight caregivers in the Mexico City Metropolitan Area who received a complementary and alternative medicine (CAM) telemedicine treatment with H 2O 2 taken by mouth (PO, at a concentration of 0.06%), oral rinse (mouthwash, 1.5%), and/or nebulization (0.2%). Given its anti-infective and oxygenating properties, hydrogen peroxide may offer prophylactic and therapeutic applications for responding to the COVID-19 pandemic. Globally, many physicians have reported using H 2O 2 successfully, in different modalities, against COVID-19. Knowledge of the antiseptic effects of hydrogen peroxide (H 2O 2) dates back to the late 19th century, and its mechanisms of action has been amply described.

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